Keene's career began on the stage, making her professional debut playing Janey in Kin at The Royal Court Theatre from 19 November to 23 December 2010. In 2013, Keene appeared in CBBC's Sadie J as Brandy May Lou and in Our Girl as Jade Dawes Between 2013 and 2015, Keene was a series regular in EastEnders, playing Cindy Williams. In 2016, Keene appeared in an episode of Casualty as Lana Westmore. Keene also played Megan in a short film, The Escape, in 2017. Keene also had voice roles for video games, Castlevania: Lords of Shadow 1 and 2.
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